Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation

Dendrimer‐N‐acetyl cysteine (D‐NAC) conjugate has shown significant promise in multiple preclinical models of brain injury and is undergoing clinical translation. D‐NAC is a generation‐4 hydroxyl‐polyamidoamine dendrimer conjugate where N‐acetyl cysteine (NAC) is covalently bound through disulfide l...

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Detalhes bibliográficos
Publicado no:Bioeng Transl Med
Main Authors: Sharma, Rishi, Sharma, Anjali, Kambhampati, Siva P., Reddy, Rajsekar Rami, Zhang, Zhi, Cleland, Jeffrey L., Kannan, Sujatha, Kannan, Rangaramanujam M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
Assuntos:
Research Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063872/
https://ncbi.nlm.nih.gov/pubmed/30065965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10094
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