Scalable synthesis and validation of PAMAM dendrimer‐N‐acetyl cysteine conjugate for potential translation

Dendrimer‐N‐acetyl cysteine (D‐NAC) conjugate has shown significant promise in multiple preclinical models of brain injury and is undergoing clinical translation. D‐NAC is a generation‐4 hydroxyl‐polyamidoamine dendrimer conjugate where N‐acetyl cysteine (NAC) is covalently bound through disulfide l...

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Detalles Bibliográficos
Publicado en:Bioeng Transl Med
Autores principales: Sharma, Rishi, Sharma, Anjali, Kambhampati, Siva P., Reddy, Rajsekar Rami, Zhang, Zhi, Cleland, Jeffrey L., Kannan, Sujatha, Kannan, Rangaramanujam M.
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2018
Materias:
Research Reports
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6063872/
https://ncbi.nlm.nih.gov/pubmed/30065965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/btm2.10094
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