Pediatric Oral Formulation of Dendrimer-N-acetyl-L-cysteine Conjugates for the Treatment of Neuroinflammation

N-acetyl-L-cysteine (NAC) commonly used as an antidote in acetaminophen poisoning has shown promise in the treatment of neurological disorders such as cerebral palsy (CP). However, NAC suffers from drawbacks such as poor oral bioavailability and suboptimal blood-brain-barrier (BBB) permeability limi...

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Publicado en:Int J Pharm
Autores principales: Yellepeddi, Venkata K, Mohammadpour, Raziye, Kambhampati, Siva P., Sayre, Casey, Mishra, Manoj K., Kannan, Rangaramanujam M, Ghandehari, Hamidreza
Formato: Artigo
Lenguaje:Inglês
Publicado: 2018
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043367/
https://ncbi.nlm.nih.gov/pubmed/29680280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2018.04.040
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