Pediatric Oral Formulation of Dendrimer-N-acetyl-L-cysteine Conjugates for the Treatment of Neuroinflammation

N-acetyl-L-cysteine (NAC) commonly used as an antidote in acetaminophen poisoning has shown promise in the treatment of neurological disorders such as cerebral palsy (CP). However, NAC suffers from drawbacks such as poor oral bioavailability and suboptimal blood-brain-barrier (BBB) permeability limi...

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Pubblicato in:Int J Pharm
Autori principali: Yellepeddi, Venkata K, Mohammadpour, Raziye, Kambhampati, Siva P., Sayre, Casey, Mishra, Manoj K., Kannan, Rangaramanujam M, Ghandehari, Hamidreza
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043367/
https://ncbi.nlm.nih.gov/pubmed/29680280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijpharm.2018.04.040
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