Glutathione boosting the cytotoxicity of a magnetic platinum(iv) nano-prodrug in tumor cells

Superparamagnetic iron oxide nanoparticles (SPIONs) are potential vehicles for targeted drug delivery and viable contrast agents for magnetic resonance imaging (MRI). A Pt(IV) prodrug (HSPt) derived from functionalization of cisplatin with hydroxyl and succinate is conjugated with a poly(ethylene gl...

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Dettagli Bibliografici
Pubblicato in:Chem Sci
Autori principali: Zhu, Zhenzhu, Wang, Zenghui, Hao, Yigang, Zhu, Chengcheng, Jiao, Yang, Chen, Huachao, Wang, Yun-Ming, Yan, Jun, Guo, Zijian, Wang, Xiaoyong
Natura: Artigo
Lingua:Inglês
Pubblicazione: Royal Society of Chemistry 2016
Soggetti:
Chemistry
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6054038/
https://ncbi.nlm.nih.gov/pubmed/30090279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc04049c
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