A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity

Flurbiprofen, a hydrophobic COX inhibitor, was coordinated axially with oxoplatin to form a new conjugate, cis,cis,trans-[Pt(IV)(NH(3))(2)Cl(2)(flurbiprofen)(2)]. The successful synthesis of this new conjugate was confirmed by (1)H, (13)C, and (195)Pt NMR. The potential of this conjugate being reduc...

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Bibliographic Details
Published in:Mol Pharm
Main Authors: Tan, Jingjie, Li, Chan, Wang, Qian, Li, Shuyi, Chen, Shizhu, Zhang, Jinchao, Wang, Paul C., Ren, Lei, Liang, Xing-Jie
Format: Artigo
Language:Inglês
Published: 2018
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7057395/
https://ncbi.nlm.nih.gov/pubmed/29522683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00070
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