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A Carrier-Free Nanostructure Based on Platinum(IV) Prodrug Enhances Cellular Uptake and Cytotoxicity
Flurbiprofen, a hydrophobic COX inhibitor, was coordinated axially with oxoplatin to form a new conjugate, cis,cis,trans-[Pt(IV)(NH(3))(2)Cl(2)(flurbiprofen)(2)]. The successful synthesis of this new conjugate was confirmed by (1)H, (13)C, and (195)Pt NMR. The potential of this conjugate being reduc...
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| Publicado no: | Mol Pharm |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7057395/ https://ncbi.nlm.nih.gov/pubmed/29522683 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.8b00070 |
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