A Platinum(IV) Prodrug—Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain

Effective delivery to the brain limits the development of novel glioblastoma therapies. Here, we introduce conjugation between platinum(IV) prodrugs of cisplatin and perfluoroaryl peptide macrocycles to increase brain uptake. We demonstrate that one such conjugate shows efficacy against glioma stem-...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Fadzen, Colin M., Wolfe, Justin M., Zhou, Wen, Cho, Choi-Fong, von Spreckelsen, Niklas, Hutchinson, Kathryn T., Lee, Yen-Chun, Chiocca, E. Antonio, Lawler, Sean E., Yilmaz, Omer H., Lippard, Stephen J., Pentelute, Bradley L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992430/
https://ncbi.nlm.nih.gov/pubmed/32410451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00022
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