A Platinum(IV) Prodrug—Perfluoroaryl Macrocyclic Peptide Conjugate Enhances Platinum Uptake in the Brain

Effective delivery to the brain limits the development of novel glioblastoma therapies. Here, we introduce conjugation between platinum(IV) prodrugs of cisplatin and perfluoroaryl peptide macrocycles to increase brain uptake. We demonstrate that one such conjugate shows efficacy against glioma stem-...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:J Med Chem
Main Authors: Fadzen, Colin M., Wolfe, Justin M., Zhou, Wen, Cho, Choi-Fong, von Spreckelsen, Niklas, Hutchinson, Kathryn T., Lee, Yen-Chun, Chiocca, E. Antonio, Lawler, Sean E., Yilmaz, Omer H., Lippard, Stephen J., Pentelute, Bradley L.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7992430/
https://ncbi.nlm.nih.gov/pubmed/32410451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.0c00022
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares