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Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier
Here we describe the utility of peptide macrocyclization through perfluoroaryl-cysteine S(N)Ar chemistry to improve the ability of peptides to cross the blood–brain barrier. Multiple macrocyclic analogues of the peptide transportan-10 were investigated that displayed increased uptake in two differen...
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| 出版年: | J Am Chem Soc |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5818988/ https://ncbi.nlm.nih.gov/pubmed/28992407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09790 |
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