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Perfluoroarene–Based Peptide Macrocycles to Enhance Penetration Across the Blood–Brain Barrier

Here we describe the utility of peptide macrocyclization through perfluoroaryl-cysteine S(N)Ar chemistry to improve the ability of peptides to cross the blood–brain barrier. Multiple macrocyclic analogues of the peptide transportan-10 were investigated that displayed increased uptake in two differen...

詳細記述

保存先:
書誌詳細
出版年:J Am Chem Soc
主要な著者: Fadzen, Colin M., Wolfe, Justin M., Cho, Choi-Fong, Chiocca, E. Antonio, Lawler, Sean E., Pentelute, Bradley L.
フォーマット: Artigo
言語:Inglês
出版事項: 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5818988/
https://ncbi.nlm.nih.gov/pubmed/28992407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b09790
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