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SCDT-02. BLOOD-BRAIN-BARRIER SPHEROIDS AS AN IN VITRO SCREENING PLATFORM FOR BRAIN-PENETRATING AGENTS

The inability of most systemically delivered therapeutics to cross the blood-brain-barrier (BBB) is considered a major barrier to effective brain cancer treatment. In malignant glioma the tumor neovasculature is known to be leaky, however invasive cells remain protected behind an intact BBB, and con...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Cho, Choi-Fong, Wolfe, Justin, Fadzen, Colin, Calligaris, David, Hornburg, Kalvis, Chiocca, E Antonio, Agar, Nathalie, Pentelute, Bradley, Lawler, Sean
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5692762/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox168.1086
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