JAK1-mediated Sirt1 phosphorylation functions as a negative feedback of the JAK1-STAT3 pathway

The type III NAD–dependent histone deacetylase Sirt1 plays important roles in a variety of pathobiological functions through targeting either the acetylated histones or transcription factors. However, the molecular mechanisms underlying how the Sirt1 functions are regulated remain vague. Herein we i...

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Vydáno v:J Biol Chem
Hlavní autoři: Wang, Wenhui, Li, Fei, Xu, Yuanming, Wei, Juncheng, Zhang, Yana, Yang, Heeyoung, Gao, Beixue, Yu, Guohua, Fang, Deyu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2018
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6052220/
https://ncbi.nlm.nih.gov/pubmed/29789426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA117.001387
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