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SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence
Human Silent Information Regulator Type 1 (SIRT1) is an NAD(+)-dependent deacetylase protein which is an intermediary of cellular metabolism in gene silencing and aging. SIRT1 has been extensively investigated and shown to delay senescence; however, less is known about the regulation of SIRT1 during...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2995042/ https://ncbi.nlm.nih.gov/pubmed/20660480 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq609 |
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