SIRT1 is regulated by a PPARγ–SIRT1 negative feedback loop associated with senescence

Human Silent Information Regulator Type 1 (SIRT1) is an NAD(+)-dependent deacetylase protein which is an intermediary of cellular metabolism in gene silencing and aging. SIRT1 has been extensively investigated and shown to delay senescence; however, less is known about the regulation of SIRT1 during...

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Detalles Bibliográficos
Main Authors: Han, Limin, Zhou, Rui, Niu, Jing, McNutt, Michael A., Wang, Pan, Tong, Tanjun
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
Assuntos:
Gene Regulation, Chromatin and Epigenetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2995042/
https://ncbi.nlm.nih.gov/pubmed/20660480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq609
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