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DYRK1A and DYRK3 Promote Cell Survival through Phosphorylation and Activation of SIRT1

DYRK1A (the dual specificity tyrosine phosphorylation-regulated kinase 1A) plays an important role in body growth and brain physiology. Overexpression of this kinase has been associated with the development of Down syndrome in both human and animal models, whereas single copy loss-of-function of DYR...

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Библиографические подробности
Главные авторы: Guo, Xiumei, Williams, Jason G., Schug, Thaddeus T., Li, Xiaoling
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857074/
https://ncbi.nlm.nih.gov/pubmed/20167603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.102574
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