Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors

Repeated cycles of intoxication and withdrawal enhance the negative reinforcing properties of alcohol and lead to neuroadaptations that underlie withdrawal symptoms driving alcohol dependence. Pharmacotherapies that target these neuroadaptations may help break the cycle of dependence. The sigma-1 re...

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Publicat a:Neuropsychopharmacology
Autors principals: Scott, Luisa L., Sahn, James J., Ferragud, Antonio, Yen, Rachel C., Satarasinghe, Praveen N., Wood, Michael D., Hodges, Timothy R., Shi, Ted, Prakash, Brooke A., Friese, Kaitlyn M., Shen, Angela, Sabino, Valentina, Pierce, Jonathan T., Martin, Stephen F.
Format: Artigo
Idioma:Inglês
Publicat: Springer International Publishing 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046036/
https://ncbi.nlm.nih.gov/pubmed/29728649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0067-z
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