Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors

Repeated cycles of intoxication and withdrawal enhance the negative reinforcing properties of alcohol and lead to neuroadaptations that underlie withdrawal symptoms driving alcohol dependence. Pharmacotherapies that target these neuroadaptations may help break the cycle of dependence. The sigma-1 re...

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Опубликовано в: :Neuropsychopharmacology
Главные авторы: Scott, Luisa L., Sahn, James J., Ferragud, Antonio, Yen, Rachel C., Satarasinghe, Praveen N., Wood, Michael D., Hodges, Timothy R., Shi, Ted, Prakash, Brooke A., Friese, Kaitlyn M., Shen, Angela, Sabino, Valentina, Pierce, Jonathan T., Martin, Stephen F.
Формат: Artigo
Язык:Inglês
Опубликовано: Springer International Publishing 2018
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046036/
https://ncbi.nlm.nih.gov/pubmed/29728649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0067-z
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