Small molecule modulators of σ2R/Tmem97 reduce alcohol withdrawal-induced behaviors

Repeated cycles of intoxication and withdrawal enhance the negative reinforcing properties of alcohol and lead to neuroadaptations that underlie withdrawal symptoms driving alcohol dependence. Pharmacotherapies that target these neuroadaptations may help break the cycle of dependence. The sigma-1 re...

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Pubblicato in:Neuropsychopharmacology
Autori principali: Scott, Luisa L., Sahn, James J., Ferragud, Antonio, Yen, Rachel C., Satarasinghe, Praveen N., Wood, Michael D., Hodges, Timothy R., Shi, Ted, Prakash, Brooke A., Friese, Kaitlyn M., Shen, Angela, Sabino, Valentina, Pierce, Jonathan T., Martin, Stephen F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer International Publishing 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6046036/
https://ncbi.nlm.nih.gov/pubmed/29728649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41386-018-0067-z
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