HIF Activation Causes Synthetic Lethality Between the VHL Tumor Suppressor and the EZH1 Histone Methyltransferase

Inactivation of the von Hippel Lindau tumor suppressor protein (pVHL) is the signature lesion in the most common form of kidney cancer, clear cell renal cell carcinoma (ccRCC). pVHL loss causes the transcriptional activation of HIF target genes, including many genes that encode histone lysine demeth...

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Pubblicato in:Sci Transl Med
Autori principali: Chakraborty, Abhishek A., Nakamura, Eijiro, Qi, Jun, Creech, Amanda, Jaffe, Jacob D., Paulk, Joshiawa, Novak, Jesse S., Nagulapalli, Kshithija, McBrayer, Samuel K., Cowley, Glenn S., Pineda, Javier, Song, Jiaxi, Wang, Yaoyu E., Carr, Steven A., Root, David E., Signoretti, Sabina, Bradner, James E., Kaelin, William G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6039096/
https://ncbi.nlm.nih.gov/pubmed/28701475
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal5272
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