Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief

Typically considered to be cell surface sensors of extracellular signals, heterotrimeric GTP-binding protein (G protein)–coupled receptors (GPCRs) control many pathophysiological processes and are the target of 30% of therapeutic drugs. Activated receptors redistribute to endosomes, but researchers...

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Publicado no:Sci Transl Med
Main Authors: Jensen, Dane D., Lieu, TinaMarie, Halls, Michelle L., Veldhuis, Nicholas A., Imlach, Wendy L., Mai, Quynh N., Poole, Daniel P., Quach, Tim, Aurelio, Luigi, Conner, Joshua, Herenbrink, Carmen Klein, Barlow, Nicholas, Simpson, Jamie S., Scanlon, Martin J., Graham, Bimbil, McCluskey, Adam, Robinson, Phillip J., Escriou, Virginie, Nassini, Romina, Materazzi, Serena, Geppetti, Pierangelo, Hicks, Gareth A., Christie, Macdonald J., Porter, Christopher J. H., Canals, Meritxell, Bunnett, Nigel W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6034632/
https://ncbi.nlm.nih.gov/pubmed/28566424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aal3447
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