Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Prostaglandins (PG) are known to induce pain perception indirectly by sensitizing nociceptors. Accordingly, the analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) results from inhibition of cyclooxygenases and blockade of PG biosynthesis. Cyclopentenone PGs, 15-d-PGJ(2), PGA(2), and P...

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Detalhes bibliográficos
Main Authors: Materazzi, Serena, Nassini, Romina, Andrè, Eunice, Campi, Barbara, Amadesi, Silvia, Trevisani, Marcello, Bunnett, Nigel W., Patacchini, Riccardo, Geppetti, Pierangelo
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575298/
https://ncbi.nlm.nih.gov/pubmed/18687886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802354105
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