Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Prostaglandins (PG) are known to induce pain perception indirectly by sensitizing nociceptors. Accordingly, the analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) results from inhibition of cyclooxygenases and blockade of PG biosynthesis. Cyclopentenone PGs, 15-d-PGJ(2), PGA(2), and P...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Materazzi, Serena, Nassini, Romina, Andrè, Eunice, Campi, Barbara, Amadesi, Silvia, Trevisani, Marcello, Bunnett, Nigel W., Patacchini, Riccardo, Geppetti, Pierangelo
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2008
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575298/
https://ncbi.nlm.nih.gov/pubmed/18687886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802354105
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