The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

BACKGROUND AND PURPOSE: Although still used by hundreds of millions of people worldwide, the mechanism of the analgesic action of the pyrazolone derivatives (PDs), dipyrone, propyphenazone and antipyrine remains unknown. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed by nocice...

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Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Nassini, Romina, Fusi, Camilla, Materazzi, Serena, Coppi, Elisabetta, Tuccinardi, Tiziano, Marone, Ilaria M, De Logu, Francesco, Preti, Delia, Tonello, Raquel, Chiarugi, Alberto, Patacchini, Riccardo, Geppetti, Pierangelo, Benemei, Silvia
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley & Sons, Ltd 2015
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500374/
https://ncbi.nlm.nih.gov/pubmed/25765567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13129
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