The anti‐migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel

BACKGROUND AND PURPOSE: The mechanism of the anti‐migraine action of extracts of butterbur [Petasites hybridus (L.) Gaertn.] is unknown. Here, we investigated the ability of isopetasin, a major constituent of these extracts, to specifically target TRPA1 channel and to affect functional responses rel...

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Publicat a:Br J Pharmacol
Autors principals: Benemei, Silvia, De Logu, Francesco, Li Puma, Simone, Marone, Ilaria Maddalena, Coppi, Elisabetta, Ugolini, Filippo, Liedtke, Wolfgang, Pollastro, Federica, Appendino, Giovanni, Geppetti, Pierangelo, Materazzi, Serena, Nassini, Romina
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5554318/
https://ncbi.nlm.nih.gov/pubmed/28622417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13917
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