Steroidal and non-steroidal third-generation aromatase inhibitors induce pain-like symptoms via TRPA1

Use of aromatase inhibitors (AIs), exemestane, letrozole and anastrozole, for breast cancer therapy is associated with severe pain symptoms, the underlying mechanism of which is unknown. The electrophilic nature of AIs suggests that they may target the transient receptor potential ankyrin 1 (TRPA1)...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Fusi, Camilla, Materazzi, Serena, Benemei, Silvia, Coppi, Elisabetta, Trevisan, Gabriela, Marone, Ilaria M., Minocci, Daiana, De Logu, Francesco, Tuccinardi, Tiziano, Di Tommaso, Maria Rosaria, Susini, Tommaso, Moneti, Gloriano, Pieraccini, Giuseppe, Geppetti, Pierangelo, Nassini, Romina
Format: Artigo
Jezik:Inglês
Izdano: Nature Pub. Group 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4268712/
https://ncbi.nlm.nih.gov/pubmed/25484020
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6736
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