The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

BACKGROUND AND PURPOSE: Although still used by hundreds of millions of people worldwide, the mechanism of the analgesic action of the pyrazolone derivatives (PDs), dipyrone, propyphenazone and antipyrine remains unknown. The transient receptor potential ankyrin 1 (TRPA1) channel, expressed by nocice...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Br J Pharmacol
Prif Awduron: Nassini, Romina, Fusi, Camilla, Materazzi, Serena, Coppi, Elisabetta, Tuccinardi, Tiziano, Marone, Ilaria M, De Logu, Francesco, Preti, Delia, Tonello, Raquel, Chiarugi, Alberto, Patacchini, Riccardo, Geppetti, Pierangelo, Benemei, Silvia
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: John Wiley & Sons, Ltd 2015
Pynciau:
Research Papers
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4500374/
https://ncbi.nlm.nih.gov/pubmed/25765567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13129
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