Cox-dependent fatty acid metabolites cause pain through activation of the irritant receptor TRPA1

Prostaglandins (PG) are known to induce pain perception indirectly by sensitizing nociceptors. Accordingly, the analgesic action of nonsteroidal anti-inflammatory drugs (NSAIDs) results from inhibition of cyclooxygenases and blockade of PG biosynthesis. Cyclopentenone PGs, 15-d-PGJ(2), PGA(2), and P...

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Autori principali: Materazzi, Serena, Nassini, Romina, Andrè, Eunice, Campi, Barbara, Amadesi, Silvia, Trevisani, Marcello, Bunnett, Nigel W., Patacchini, Riccardo, Geppetti, Pierangelo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2008
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2575298/
https://ncbi.nlm.nih.gov/pubmed/18687886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0802354105
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