Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma membrane, where they interact with extracellular ligands and couple to G proteins that transmit intracellular signals. Consequently, therapeutic drugs are designed to target GPCRs at the plasma membrane. Activated...

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發表在:Proc Natl Acad Sci U S A
Main Authors: Yarwood, Rebecca E., Imlach, Wendy L., Lieu, TinaMarie, Veldhuis, Nicholas A., Jensen, Dane D., Klein Herenbrink, Carmen, Aurelio, Luigi, Cai, Zhijian, Christie, MacDonald J., Poole, Daniel P., Porter, Christopher J. H., McLean, Peter, Hicks, Gareth A., Geppetti, Pierangelo, Halls, Michelle L., Canals, Meritxell, Bunnett, Nigel W.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2017
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699040/
https://ncbi.nlm.nih.gov/pubmed/29087309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706656114
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