Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission

G protein-coupled receptors (GPCRs) are considered to function primarily at the plasma membrane, where they interact with extracellular ligands and couple to G proteins that transmit intracellular signals. Consequently, therapeutic drugs are designed to target GPCRs at the plasma membrane. Activated...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Yarwood, Rebecca E., Imlach, Wendy L., Lieu, TinaMarie, Veldhuis, Nicholas A., Jensen, Dane D., Klein Herenbrink, Carmen, Aurelio, Luigi, Cai, Zhijian, Christie, MacDonald J., Poole, Daniel P., Porter, Christopher J. H., McLean, Peter, Hicks, Gareth A., Geppetti, Pierangelo, Halls, Michelle L., Canals, Meritxell, Bunnett, Nigel W.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5699040/
https://ncbi.nlm.nih.gov/pubmed/29087309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1706656114
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