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Therapeutic Targeting of Endosomal G-Protein-Coupled Receptors
G-protein-coupled receptors (GPCRs) are conventionally considered to function at the plasma membrane, where they detect extracellular ligands and activate heterotrimeric G proteins that transmit intracellular signals. Consequently, drug discovery efforts have focused on identification of agonists an...
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| Publicado no: | Trends Pharmacol Sci |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6508874/ https://ncbi.nlm.nih.gov/pubmed/30180973 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2018.08.003 |
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