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Therapeutic Targeting of Endosomal G-Protein-Coupled Receptors

G-protein-coupled receptors (GPCRs) are conventionally considered to function at the plasma membrane, where they detect extracellular ligands and activate heterotrimeric G proteins that transmit intracellular signals. Consequently, drug discovery efforts have focused on identification of agonists an...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Trends Pharmacol Sci
Main Authors: Thomsen, Alex R.B., Jensen, Dane D., Hicks, Gareth A., Bunnett, Nigel W.
Format: Artigo
Jezik:Inglês
Izdano: 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6508874/
https://ncbi.nlm.nih.gov/pubmed/30180973
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tips.2018.08.003
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