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Engineering therapeutic antibodies targeting G-protein–coupled receptors

G-protein–coupled receptors (GPCRs) are one of the most attractive therapeutic target classes because of their critical roles in intracellular signaling and their clinical relevance to a variety of diseases, including cancer, infection and inflammation. However, high conformational variability, the...

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Pubblicato in:Exp Mol Med
Autori principali: Jo, Migyeong, Jung, Sang Taek
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4892866/
https://ncbi.nlm.nih.gov/pubmed/26846450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emm.2015.105
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