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Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer

A synthetic lethality–based strategy has been developed to identify therapeutic targets in cancer harboring tumor-suppressor gene mutations, as exemplified by the effectiveness of poly ADP-ribose polymerase (PARP) inhibitors in BRCA1/2-mutated tumors. However, many synthetic lethal interactors are l...

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שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Clin Invest
Main Authors: Liu, Yunhua, Xu, Hanchen, Van der Jeught, Kevin, Li, Yujing, Liu, Sheng, Zhang, Lu, Fang, Yuanzhang, Zhang, Xinna, Radovich, Milan, Schneider, Bryan P., He, Xiaoming, Huang, Cheng, Zhang, Chi, Wan, Jun, Ji, Guang, Lu, Xiongbin
פורמט: Artigo
שפה:Inglês
יצא לאור: American Society for Clinical Investigation 2018
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025969/
https://ncbi.nlm.nih.gov/pubmed/29649003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98727
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