Intratumoral delivery of mRNA: Overcoming obstacles for effective immunotherapy

por Van der Jeught, Kevin, Van Lint, Sandra, Thielemans, Kris, Breckpot, Karine
Publicado en Oncoimmunology (2015)

Drug resistance and new therapies in colorectal cancer

por Van der Jeught, Kevin, Xu, Han-Chen, Li, Yu-Jing, Lu, Xiong-Bin, Ji, Guang
Publicado en World J Gastroenterol (2018)

Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity

por Van der Jeught, Kevin, Joe, Patrick Tjok, Bialkowski, Lukasz, Heirman, Carlo, Daszkiewicz, Lidia, Liechtenstein, Therese, Escors, David, Thielemans, Kris, Breckpot, Karine
Publicado en Oncotarget (2014)

Particle-mediated Intravenous Delivery of Antigen mRNA Results in Strong Antigen-specific T-cell Responses Despite the Induction of Type I Interferon

por Broos, Katrijn, Van der Jeught, Kevin, Puttemans, Janik, Goyvaerts, Cleo, Heirman, Carlo, Dewitte, Heleen, Verbeke, Rein, Lentacker, Ine, Thielemans, Kris, Breckpot, Karine
Publicado en Mol Ther Nucleic Acids (2016)

Targeting the tumor microenvironment to enhance antitumor immune responses

por Van der Jeught, Kevin, Bialkowski, Lukasz, Daszkiewicz, Lidia, Broos, Katrijn, Goyvaerts, Cleo, Renmans, Dries, Van Lint, Sandra, Heirman, Carlo, Thielemans, Kris, Breckpot, Karine
Publicado en Oncotarget (2014)

Intralymphatic mRNA vaccine induces CD8 T-cell responses that inhibit the growth of mucosally located tumours

por Bialkowski, Lukasz, van Weijnen, Alexia, Van der Jeught, Kevin, Renmans, Dries, Daszkiewicz, Lidia, Heirman, Carlo, Stangé, Geert, Breckpot, Karine, Aerts, Joeri L., Thielemans, Kris
Publicado en Sci Rep (2016)

Precise targeting of POLR2A as a therapeutic strategy for human triple negative breast cancer

por Xu, Jiangsheng, Liu, Yunhua, Li, Yujing, Wang, Hai, Stewart, Samantha, Van der Jeught, Kevin, Agarwal, Pranay, Zhang, Yuntian, Liu, Sheng, Zhao, Gang, Wan, Jun, Lu, Xiongbin, He, Xiaoming
Publicado en Nat Nanotechnol (2019)

A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice

por Liechtenstein, Therese, Perez-Janices, Noemi, Gato, Maria, Caliendo, Fabio, Kochan, Grazyna, Blanco-Luquin, Idoia, Van der Jeught, Kevin, Arce, Frederick, Guerrero-Setas, David, Fernandez-Irigoyen, Joaquin, Santamaria, Enrique, Breckpot, Karine, Escors, David
Publicado 2014

Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer

por Liu, Yunhua, Xu, Hanchen, Van der Jeught, Kevin, Li, Yujing, Liu, Sheng, Zhang, Lu, Fang, Yuanzhang, Zhang, Xinna, Radovich, Milan, Schneider, Bryan P., He, Xiaoming, Huang, Cheng, Zhang, Chi, Wan, Jun, Ji, Guang, Lu, Xiongbin
Publicado en J Clin Invest (2018)

ST2 as checkpoint target for colorectal cancer immunotherapy

por Van der Jeught, Kevin, Sun, Yifan, Fang, Yuanzhang, Zhou, Zhuolong, Jiang, Hua, Yu, Tao, Yang, Jinfeng, Kamocka, Malgorzata M., So, Ka Man, Li, Yujing, Eyvani, Haniyeh, Sandusky, George E., Frieden, Michael, Braun, Harald, Beyaert, Rudi, He, Xiaoming, Zhang, Xinna, Zhang, Chi, Paczesny, Sophie, Lu, Xiongbin
Publicado en JCI Insight (2020)

Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II

por Li, Yujing, Liu, Yunhua, Xu, Hanchen, Jiang, Guanglong, Van der Jeught, Kevin, Fang, Yuanzhang, Zhou, Zhuolong, Zhang, Lu, Frieden, Michael, Wang, Lifei, Luo, Zhenhua, Radovich, Milan, Schneider, Bryan P., Deng, Yibin, Liu, Yunlong, Huang, Kun, He, Bin, Wang, Jin, He, Xiaoming, Zhang, Xinna, Ji, Guang, Lu, Xiongbin
Publicado en Nat Commun (2018)

Targeting 17q23 amplicon to overcome the resistance to anti-HER2 therapy in HER2+ breast cancer

por Liu, Yunhua, Xu, Jiangsheng, Choi, Hyun Ho, Han, Cecil, Fang, Yuanzhang, Li, Yujing, Van der Jeught, Kevin, Xu, Hanchen, Zhang, Lu, Frieden, Michael, Wang, Lifei, Eyvani, Haniyeh, Sun, Yifan, Zhao, Gang, Zhang, Yuntian, Liu, Sheng, Wan, Jun, Huang, Cheng, Ji, Guang, Lu, Xiongbin, He, Xiaoming, Zhang, Xinna
Publicado en Nat Commun (2018)

MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation

por Fang, Yuanzhang, Wang, Lifei, Wan, Changlin, Sun, Yifan, Van der Jeught, Kevin, Zhou, Zhuolong, Dong, Tianhan, So, Ka Man, Yu, Tao, Li, Yujing, Eyvani, Haniyeh, Colter, Austyn B., Dong, Edward, Cao, Sha, Wang, Jin, Schneider, Bryan P., Sandusky, George E., Liu, Yunlong, Zhang, Chi, Lu, Xiongbin, Zhang, Xinna
Publicado en J Clin Invest (2021)

Atractylenolide I enhances responsiveness to immune checkpoint blockade therapy by activating tumor antigen presentation

por Xu, Hanchen, Van der Jeught, Kevin, Zhou, Zhuolong, Zhang, Lu, Yu, Tao, Sun, Yifan, Li, Yujing, Wan, Changlin, So, Ka Man, Liu, Degang, Frieden, Michael, Fang, Yuanzhang, Mosley, Amber L., He, Xiaoming, Zhang, Xinna, Sandusky, George E., Liu, Yunlong, Meroueh, Samy O., Zhang, Chi, Wijeratne, Aruna B., Huang, Cheng, Ji, Guang, Lu, Xiongbin
Publicado en J Clin Invest (2021)