MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation

Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells, current immune checkpoint therapy is set to boost CD8(+) T cell–mediated cytotoxicity. However, this action is eventually dependent on the efficient recognition of tumor-specific antigens via T cell receptors. O...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Principais autores: Fang, Yuanzhang, Wang, Lifei, Wan, Changlin, Sun, Yifan, Van der Jeught, Kevin, Zhou, Zhuolong, Dong, Tianhan, So, Ka Man, Yu, Tao, Li, Yujing, Eyvani, Haniyeh, Colter, Austyn B., Dong, Edward, Cao, Sha, Wang, Jin, Schneider, Bryan P., Sandusky, George E., Liu, Yunlong, Zhang, Chi, Lu, Xiongbin, Zhang, Xinna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2021
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773365/
https://ncbi.nlm.nih.gov/pubmed/32990678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140837
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