MAL2 drives immune evasion in breast cancer by suppressing tumor antigen presentation

Immune evasion is a pivotal event in tumor progression. To eliminate human cancer cells, current immune checkpoint therapy is set to boost CD8(+) T cell–mediated cytotoxicity. However, this action is eventually dependent on the efficient recognition of tumor-specific antigens via T cell receptors. O...

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Udgivet i:J Clin Invest
Main Authors: Fang, Yuanzhang, Wang, Lifei, Wan, Changlin, Sun, Yifan, Van der Jeught, Kevin, Zhou, Zhuolong, Dong, Tianhan, So, Ka Man, Yu, Tao, Li, Yujing, Eyvani, Haniyeh, Colter, Austyn B., Dong, Edward, Cao, Sha, Wang, Jin, Schneider, Bryan P., Sandusky, George E., Liu, Yunlong, Zhang, Chi, Lu, Xiongbin, Zhang, Xinna
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2021
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7773365/
https://ncbi.nlm.nih.gov/pubmed/32990678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI140837
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