Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II

Heterozygous deletion of chromosome 17p (17p) is one of the most frequent genomic events in human cancers. Beyond the tumor suppressor TP53, the POLR2A gene encoding the catalytic subunit of RNA polymerase II (RNAP2) is also included in a ~20-megabase deletion region of 17p in 63% of metastatic cast...

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Udgivet i:Nat Commun
Main Authors: Li, Yujing, Liu, Yunhua, Xu, Hanchen, Jiang, Guanglong, Van der Jeught, Kevin, Fang, Yuanzhang, Zhou, Zhuolong, Zhang, Lu, Frieden, Michael, Wang, Lifei, Luo, Zhenhua, Radovich, Milan, Schneider, Bryan P., Deng, Yibin, Liu, Yunlong, Huang, Kun, He, Bin, Wang, Jin, He, Xiaoming, Zhang, Xinna, Ji, Guang, Lu, Xiongbin
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6197287/
https://ncbi.nlm.nih.gov/pubmed/30349055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06811-z
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