Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer

A synthetic lethality–based strategy has been developed to identify therapeutic targets in cancer harboring tumor-suppressor gene mutations, as exemplified by the effectiveness of poly ADP-ribose polymerase (PARP) inhibitors in BRCA1/2-mutated tumors. However, many synthetic lethal interactors are l...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Liu, Yunhua, Xu, Hanchen, Van der Jeught, Kevin, Li, Yujing, Liu, Sheng, Zhang, Lu, Fang, Yuanzhang, Zhang, Xinna, Radovich, Milan, Schneider, Bryan P., He, Xiaoming, Huang, Cheng, Zhang, Chi, Wan, Jun, Ji, Guang, Lu, Xiongbin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025969/
https://ncbi.nlm.nih.gov/pubmed/29649003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98727
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