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Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer
A synthetic lethality–based strategy has been developed to identify therapeutic targets in cancer harboring tumor-suppressor gene mutations, as exemplified by the effectiveness of poly ADP-ribose polymerase (PARP) inhibitors in BRCA1/2-mutated tumors. However, many synthetic lethal interactors are l...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | J Clin Invest |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
American Society for Clinical Investigation
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6025969/ https://ncbi.nlm.nih.gov/pubmed/29649003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98727 |
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