Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer

A synthetic lethality–based strategy has been developed to identify therapeutic targets in cancer harboring tumor-suppressor gene mutations, as exemplified by the effectiveness of poly ADP-ribose polymerase (PARP) inhibitors in BRCA1/2-mutated tumors. However, many synthetic lethal interactors are l...

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Dettagli Bibliografici
Pubblicato in:J Clin Invest
Autori principali: Liu, Yunhua, Xu, Hanchen, Van der Jeught, Kevin, Li, Yujing, Liu, Sheng, Zhang, Lu, Fang, Yuanzhang, Zhang, Xinna, Radovich, Milan, Schneider, Bryan P., He, Xiaoming, Huang, Cheng, Zhang, Chi, Wan, Jun, Ji, Guang, Lu, Xiongbin
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6025969/
https://ncbi.nlm.nih.gov/pubmed/29649003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI98727
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