Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice

Epidermal growth factor receptor (EGFR) plays a crucial role in hepatocyte proliferation. Its role in acetaminophen (APAP)-mediated hepatotoxicity and subsequent liver regeneration is completely unknown. Role of EGFR after APAP-overdose in mice was studied using pharmacological inhibition strategy....

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Bibliographische Detailangaben
Veröffentlicht in:Toxicol Sci
Hauptverfasser: Bhushan, Bharat, Chavan, Hemantkumar, Borude, Prachi, Xie, Yuchao, Du, Kuo, McGill, Mitchell R, Lebofsky, Margitta, Jaeschke, Hartmut, Krishnamurthy, Partha, Apte, Udayan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
Schlagworte:
EGF Receptor in Acetaminophen-Mediated Liver Toxicity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020708/
https://ncbi.nlm.nih.gov/pubmed/28123000
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw213
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