Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling pathway that targets Glioma-associated oncogene homologue (Gli) proteins, and at confirming the chemical nature of its bioactive form. GANT61 is...

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Veröffentlicht in:J Enzyme Inhib Med Chem
Hauptverfasser: Calcaterra, Andrea, Iovine, Valentina, Botta, Bruno, Quaglio, Deborah, D’Acquarica, Ilaria, Ciogli, Alessia, Iazzetti, Antonia, Alfonsi, Romina, Lospinoso Severini, Ludovica, Infante, Paola, Di Marcotullio, Lucia, Mori, Mattia, Ghirga, Francesca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009951/
https://ncbi.nlm.nih.gov/pubmed/29338454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1419221
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