Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

This work aims at elucidating the mechanism and kinetics of hydrolysis of GANT61, the first and most-widely used inhibitor of the Hedgehog (Hh) signalling pathway that targets Glioma-associated oncogene homologue (Gli) proteins, and at confirming the chemical nature of its bioactive form. GANT61 is...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Enzyme Inhib Med Chem
Main Authors: Calcaterra, Andrea, Iovine, Valentina, Botta, Bruno, Quaglio, Deborah, D’Acquarica, Ilaria, Ciogli, Alessia, Iazzetti, Antonia, Alfonsi, Romina, Lospinoso Severini, Ludovica, Infante, Paola, Di Marcotullio, Lucia, Mori, Mattia, Ghirga, Francesca
Format: Artigo
Jezik:Inglês
Izdano: Taylor & Francis 2018
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009951/
https://ncbi.nlm.nih.gov/pubmed/29338454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2017.1419221
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