Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

Hedgehog (Hh) inhibitors have emerged as valid tools in the treatment of a wide range of cancers. Indeed, aberrant activation of the Hh pathway occurring either by ligand-dependent or -independent mechanisms is a key driver in tumorigenesis. The smoothened (Smo) receptor is one of the main upstream...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Death Dis
Hauptverfasser: Infante, Paola, Alfonsi, Romina, Ingallina, Cinzia, Quaglio, Deborah, Ghirga, Francesca, D'Acquarica, Ilaria, Bernardi, Flavia, Di Magno, Laura, Canettieri, Gianluca, Screpanti, Isabella, Gulino, Alberto, Botta, Bruno, Mori, Mattia, Di Marcotullio, Lucia
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5059851/
https://ncbi.nlm.nih.gov/pubmed/27899820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2016.195
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