Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result of genetic mutations of pathway components or other Smo-dependent or independent mechanisms, all triggering the downstre...

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Vydáno v:EMBO J
Hlavní autoři: Infante, Paola, Mori, Mattia, Alfonsi, Romina, Ghirga, Francesca, Aiello, Federica, Toscano, Sara, Ingallina, Cinzia, Siler, Mariangela, Cucchi, Danilo, Po, Agnese, Miele, Evelina, D'Amico, Davide, Canettieri, Gianluca, De Smaele, Enrico, Ferretti, Elisabetta, Screpanti, Isabella, Uccello Barretta, Gloria, Botta, Maurizio, Botta, Bruno, Gulino, Alberto, Di Marcotullio, Lucia
Médium: Artigo
Jazyk:Inglês
Vydáno: BlackWell Publishing Ltd 2015
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298015/
https://ncbi.nlm.nih.gov/pubmed/25476449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489213
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