Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

Hedgehog signaling is essential for tissue development and stemness, and its deregulation has been observed in many tumors. Aberrant activation of Hedgehog signaling is the result of genetic mutations of pathway components or other Smo-dependent or independent mechanisms, all triggering the downstre...

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Bibliographic Details
Published in:EMBO J
Main Authors: Infante, Paola, Mori, Mattia, Alfonsi, Romina, Ghirga, Francesca, Aiello, Federica, Toscano, Sara, Ingallina, Cinzia, Siler, Mariangela, Cucchi, Danilo, Po, Agnese, Miele, Evelina, D'Amico, Davide, Canettieri, Gianluca, De Smaele, Enrico, Ferretti, Elisabetta, Screpanti, Isabella, Uccello Barretta, Gloria, Botta, Maurizio, Botta, Bruno, Gulino, Alberto, Di Marcotullio, Lucia
Format: Artigo
Language:Inglês
Published: BlackWell Publishing Ltd 2015
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4298015/
https://ncbi.nlm.nih.gov/pubmed/25476449
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201489213
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