Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy

The morphogenic Hedgehog (Hh) signaling regulates postnatal cerebellar development and its aberrant activation leads to medulloblastoma. The transcription factors Gli1 and Gli2 are the activators of Hh pathway and their function is finely controlled by different covalent modifications, such as phosp...

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Hlavní autoři: Coni, Sonia, Antonucci, Laura, D'Amico, Davide, Di Magno, Laura, Infante, Paola, De Smaele, Enrico, Giannini, Giuseppe, Di Marcotullio, Lucia, Screpanti, Isabella, Gulino, Alberto, Canettieri, Gianluca
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675076/
https://ncbi.nlm.nih.gov/pubmed/23762415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065718
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