β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells

BACKGROUND: Aberrant Sonic Hedgehog/Gli (Hh/Gli) signaling pathway is a critical regulator of Sonic hedgehog medulloblastoma (SHH-MB). Cancer stem cells (CSCs), thought to be largely responsible for tumor initiation, maintenance, dissemination and relapse, have been identified in SHH-MB. Since we pr...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Miele, Evelina, Po, Agnese, Begalli, Federica, Antonucci, Laura, Mastronuzzi, Angela, Marras, Carlo Efisio, Carai, Andrea, Cucchi, Danilo, Abballe, Luana, Besharat, Zein Mersini, Catanzaro, Giuseppina, Infante, Paola, Di Marcotullio, Lucia, Canettieri, Gianluca, De Smaele, Enrico, Screpanti, Isabella, Locatelli, Franco, Ferretti, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512842/
https://ncbi.nlm.nih.gov/pubmed/28716052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3477-0
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