β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells

BACKGROUND: Aberrant Sonic Hedgehog/Gli (Hh/Gli) signaling pathway is a critical regulator of Sonic hedgehog medulloblastoma (SHH-MB). Cancer stem cells (CSCs), thought to be largely responsible for tumor initiation, maintenance, dissemination and relapse, have been identified in SHH-MB. Since we pr...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:BMC Cancer
Main Authors: Miele, Evelina, Po, Agnese, Begalli, Federica, Antonucci, Laura, Mastronuzzi, Angela, Marras, Carlo Efisio, Carai, Andrea, Cucchi, Danilo, Abballe, Luana, Besharat, Zein Mersini, Catanzaro, Giuseppina, Infante, Paola, Di Marcotullio, Lucia, Canettieri, Gianluca, De Smaele, Enrico, Screpanti, Isabella, Locatelli, Franco, Ferretti, Elisabetta
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5512842/
https://ncbi.nlm.nih.gov/pubmed/28716052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-017-3477-0
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker