Downregulation of miR‐326 and its host gene β‐arrestin1 induces pro‐survival activity of E2F1 and promotes medulloblastoma growth

Persistent mortality rates of medulloblastoma (MB) and severe side effects of the current therapies require the definition of the molecular mechanisms that contribute to tumor progression. Using cultured MB cancer stem cells and xenograft tumors generated in mice, we show that low expression of miR‐...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Miele, Evelina, Po, Agnese, Mastronuzzi, Angela, Carai, Andrea, Besharat, Zein Mersini, Pediconi, Natalia, Abballe, Luana, Catanzaro, Giuseppina, Sabato, Claudia, De Smaele, Enrico, Canettieri, Gianluca, Di Marcotullio, Lucia, Vacca, Alessandra, Mai, Antonello, Levrero, Massimo, Pfister, Stefan M., Kool, Marcel, Giangaspero, Felice, Locatelli, Franco, Ferretti, Elisabetta
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7858128/
https://ncbi.nlm.nih.gov/pubmed/32920979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/1878-0261.12800
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