PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

The Hedgehog (Hh) signaling regulates tissue development, and its aberrant activation is a leading cause of malignancies, including medulloblastoma (Mb). Hh-dependent tumorigenesis often occurs in synergy with other mechanisms, such as loss of p53, the master regulator of the DNA damage response. To...

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Hlavní autoři: Mazzà, D, Infante, P, Colicchia, V, Greco, A, Alfonsi, R, Siler, M, Antonucci, L, Po, A, De Smaele, E, Ferretti, E, Capalbo, C, Bellavia, D, Canettieri, G, Giannini, G, Screpanti, I, Gulino, A, Di Marcotullio, L
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2013
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Original Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824589/
https://ncbi.nlm.nih.gov/pubmed/24013724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.120
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