The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint

Hedgehog signaling controls proliferation of cerebellar granule cell precursors (GCPs) and its aberrant activation is a leading cause of Medulloblastoma, the most frequent pediatric brain tumor. We show here that the energy sensor AMPK inhibits Hh signaling by phosphorylating a single residue of hum...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Di Magno, Laura, Basile, Alessio, Coni, Sonia, Manni, Simona, Sdruscia, Giulia, D'Amico, Davide, Antonucci, Laura, Infante, Paola, De Smaele, Enrico, Cucchi, Danilo, Ferretti, Elisabetta, Di Marcotullio, Lucia, Screpanti, Isabella, Canettieri, Gianluca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2016
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891058/
https://ncbi.nlm.nih.gov/pubmed/26843621
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7070
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