Gli2 Acetylation at Lysine 757 Regulates Hedgehog-Dependent Transcriptional Output by Preventing Its Promoter Occupancy

The morphogenic Hedgehog (Hh) signaling regulates postnatal cerebellar development and its aberrant activation leads to medulloblastoma. The transcription factors Gli1 and Gli2 are the activators of Hh pathway and their function is finely controlled by different covalent modifications, such as phosp...

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Autors principals: Coni, Sonia, Antonucci, Laura, D'Amico, Davide, Di Magno, Laura, Infante, Paola, De Smaele, Enrico, Giannini, Giuseppe, Di Marcotullio, Lucia, Screpanti, Isabella, Gulino, Alberto, Canettieri, Gianluca
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675076/
https://ncbi.nlm.nih.gov/pubmed/23762415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065718
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